FKBP12 Dimerization Mutations Effect FK506 Binding and Differentially Alter Calcineurin Inhibition in the Human Pathogen Aspergillus fumigatus

The 12-kDa FK506-binding protein (FKBP12) is the target of the commonly used immunosuppressive drug FK506. The FKBP12-FK506 complex binds to calcineurin and inhibits its activity, leading to immunosuppression and preventing organ transplant rejection. Our recent characterization of crystal structure...

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Publicado en:Biochem Biophys Res Commun
Autores principales: Juvvadi, Praveen R., Bobay, Benjamin G., Gobeil, Sophie M.C., Cole, D. Christopher, Venters, Ronald A., Heitman, Joseph, Spicer, Leonard D., Steinbach, William J.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2020
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7188580/
https://ncbi.nlm.nih.gov/pubmed/32192767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2020.03.062
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