Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents

Calcineurin is important for fungal virulence and a potential antifungal target, but compounds targeting calcineurin, such as FK506, are immunosuppressive. Here we report the crystal structures of calcineurin catalytic (CnA) and regulatory (CnB) subunits complexed with FK506 and the FK506-binding pr...

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Vydáno v:Nat Commun
Hlavní autoři: Juvvadi, Praveen R., Fox, David, Bobay, Benjamin G., Hoy, Michael J., Gobeil, Sophie M. C., Venters, Ronald A., Chang, Zanetta, Lin, Jackie J., Averette, Anna Floyd, Cole, D. Christopher, Barrington, Blake C., Wheaton, Joshua D., Ciofani, Maria, Trzoss, Michael, Li, Xiaoming, Lee, Soo Chan, Chen, Ying-Lien, Mutz, Mitchell, Spicer, Leonard D., Schumacher, Maria A., Heitman, Joseph, Steinbach, William J.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6753081/
https://ncbi.nlm.nih.gov/pubmed/31537789
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12199-1
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