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FKBP12 Dimerization Mutations Effect FK506 Binding and Differentially Alter Calcineurin Inhibition in the Human Pathogen Aspergillus fumigatus
The 12-kDa FK506-binding protein (FKBP12) is the target of the commonly used immunosuppressive drug FK506. The FKBP12-FK506 complex binds to calcineurin and inhibits its activity, leading to immunosuppression and preventing organ transplant rejection. Our recent characterization of crystal structure...
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| Udgivet i: | Biochem Biophys Res Commun |
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| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2020
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7188580/ https://ncbi.nlm.nih.gov/pubmed/32192767 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2020.03.062 |
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