LOSS OF THE TUMOR SUPPRESSOR, TP53, ENHANCES THE ANDROGEN RECEPTOR MEDIATED ONCOGENIC TRANSFORMATION AND TUMOR DEVELOPMENT IN THE MOUSE PROSTATE

Recent genome analysis of human prostate cancers demonstrated that both AR gene amplification and TP53 mutation are among the most frequently observed alterations in advanced prostate cancer. However, the biological role of these dual genetic alterations in prostate tumorigenesis is largely unknown....

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: He, Yongfeng, Johnson, Daniel T., Yang, Julie S., Wu, Huiqing, You, Sungyong, Yoon, Junhee, Lee, Dong-Hong, Kim, Won Kyung, Aldahl, Joseph, Le, Vien, Hooker, Erika, Yu, Eun-Jeong, Geardts, Joseph, Cardiff, Robert D., Sun, Zijie
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6752978/
https://ncbi.nlm.nih.gov/pubmed/31358900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0901-8
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