The comprehensive role of E-cadherin in maintaining prostatic epithelial integrity during oncogenic transformation and tumor progression

E-cadherin complexes with the actin cytoskeleton via cytoplasmic catenins and maintains the functional characteristics and integrity of the epithelia in normal epithelial tissues. Lost expression of E-cadherin disrupts this complex resulting in loss of cell polarity, epithelial denudation and increa...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:PLoS Genet
Main Authors: Olson, Adam, Le, Vien, Aldahl, Joseph, Yu, Eun-Jeong, Hooker, Erika, He, Yongfeng, Lee, Dong-Hong, Kim, Won Kyung, Cardiff, Robert D., Geradts, Joseph, Sun, Zijie
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2019
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6816545/
https://ncbi.nlm.nih.gov/pubmed/31658259
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1008451
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