Deletion of the p16(INK4a) tumor suppressor and expression of the androgen receptor induce sarcomatoid carcinomas with signet ring cells in the mouse prostate

The tumor suppressor p16(Ink4a), encoded by the INK4a gene, is an inhibitor of cyclin D-dependent kinases 4 and 6, CDK4 and CDK6. This inhibition prevents the phosphorylation of the retinoblastoma protein (pRb), resulting in cellular senescence through inhibition of E2F-mediated transcription of S p...

詳細記述

保存先:
書誌詳細
出版年:PLoS One
主要な著者: Lee, Dong-Hong, Yu, Eun-Jeong, Aldahl, Joseph, Yang, Julie, He, Yongfeng, Hooker, Erika, Le, Vien, Mi, Jiaqi, Olson, Adam, Wu, Huiqing, Geradts, Joseph, Xiao, Guang Q., Gonzalgo, Mark L., Cardiff, Robert D., Sun, Zijie
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2019
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345450/
https://ncbi.nlm.nih.gov/pubmed/30677079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0211153
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