Deletion of the p16(INK4a) tumor suppressor and expression of the androgen receptor induce sarcomatoid carcinomas with signet ring cells in the mouse prostate

The tumor suppressor p16(Ink4a), encoded by the INK4a gene, is an inhibitor of cyclin D-dependent kinases 4 and 6, CDK4 and CDK6. This inhibition prevents the phosphorylation of the retinoblastoma protein (pRb), resulting in cellular senescence through inhibition of E2F-mediated transcription of S p...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Lee, Dong-Hong, Yu, Eun-Jeong, Aldahl, Joseph, Yang, Julie, He, Yongfeng, Hooker, Erika, Le, Vien, Mi, Jiaqi, Olson, Adam, Wu, Huiqing, Geradts, Joseph, Xiao, Guang Q., Gonzalgo, Mark L., Cardiff, Robert D., Sun, Zijie
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345450/
https://ncbi.nlm.nih.gov/pubmed/30677079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0211153
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