Deletion of the p16(INK4a) tumor suppressor and expression of the androgen receptor induce sarcomatoid carcinomas with signet ring cells in the mouse prostate

The tumor suppressor p16(Ink4a), encoded by the INK4a gene, is an inhibitor of cyclin D-dependent kinases 4 and 6, CDK4 and CDK6. This inhibition prevents the phosphorylation of the retinoblastoma protein (pRb), resulting in cellular senescence through inhibition of E2F-mediated transcription of S p...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Lee, Dong-Hong, Yu, Eun-Jeong, Aldahl, Joseph, Yang, Julie, He, Yongfeng, Hooker, Erika, Le, Vien, Mi, Jiaqi, Olson, Adam, Wu, Huiqing, Geradts, Joseph, Xiao, Guang Q., Gonzalgo, Mark L., Cardiff, Robert D., Sun, Zijie
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6345450/
https://ncbi.nlm.nih.gov/pubmed/30677079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0211153
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