LOSS OF THE TUMOR SUPPRESSOR, TP53, ENHANCES THE ANDROGEN RECEPTOR MEDIATED ONCOGENIC TRANSFORMATION AND TUMOR DEVELOPMENT IN THE MOUSE PROSTATE

Recent genome analysis of human prostate cancers demonstrated that both AR gene amplification and TP53 mutation are among the most frequently observed alterations in advanced prostate cancer. However, the biological role of these dual genetic alterations in prostate tumorigenesis is largely unknown....

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Enregistré dans:
Détails bibliographiques
Publié dans:Oncogene
Auteurs principaux: He, Yongfeng, Johnson, Daniel T., Yang, Julie S., Wu, Huiqing, You, Sungyong, Yoon, Junhee, Lee, Dong-Hong, Kim, Won Kyung, Aldahl, Joseph, Le, Vien, Hooker, Erika, Yu, Eun-Jeong, Geardts, Joseph, Cardiff, Robert D., Sun, Zijie
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6752978/
https://ncbi.nlm.nih.gov/pubmed/31358900
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-0901-8
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