The functional impact of variants of uncertain significance in BRCA2

PURPOSE: Genetic testing has uncovered large numbers of variants in the BRCA2 gene for which the clinical significance is unclear. Cancer risk prediction of these variants of uncertain significance (VUS) can be improved by reliable assessment of the extent of impairment of the tumor suppressor funct...

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Udgivet i:Genet Med
Main Authors: Mesman, Romy L. S., Calléja, Fabienne M. G. R., Hendriks, Giel, Morolli, Bruno, Misovic, Branislav, Devilee, Peter, van Asperen, Christi J., Vrieling, Harry, Vreeswijk, Maaike P. G.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group US 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6752316/
https://ncbi.nlm.nih.gov/pubmed/29988080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41436-018-0052-2
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