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The functional impact of variants of uncertain significance in BRCA2
PURPOSE: Genetic testing has uncovered large numbers of variants in the BRCA2 gene for which the clinical significance is unclear. Cancer risk prediction of these variants of uncertain significance (VUS) can be improved by reliable assessment of the extent of impairment of the tumor suppressor funct...
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| Publicado no: | Genet Med |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group US
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6752316/ https://ncbi.nlm.nih.gov/pubmed/29988080 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41436-018-0052-2 |
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