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SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors
The cyclin-dependent kinase 4/6 (CDK4/6) kinase is dysregulated in melanoma, highlighting it as a potential therapeutic target. CDK4/6 inhibitors are being evaluated in trials for melanoma and additional cancers. While beneficial, resistance to therapy is a concern, and the molecular mechanisms of s...
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| Publicado no: | Sci Adv |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Association for the Advancement of Science
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6750908/ https://ncbi.nlm.nih.gov/pubmed/31555743 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/sciadv.aax6352 |
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