De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives

[Image: see text] Targeted protein degradation via cereblon (CRBN), a substrate receptor of an E3 ubiquitin ligase complex, is an increasingly important strategy in various clinical settings, in which the substrate specificity of CRBN is altered via the binding of small-molecule effectors. To date,...

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Publicat a:J Med Chem
Autors principals: Heim, Christopher, Pliatsika, Dimanthi, Mousavizadeh, Farnoush, Bär, Kerstin, Hernandez Alvarez, Birte, Giannis, Athanassios, Hartmann, Marcus D.
Format: Artigo
Idioma:Inglês
Publicat: American Chemical Society 2019
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750895/
https://ncbi.nlm.nih.gov/pubmed/31251063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.9b00454
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