Insights into the pathogenesis of catecholaminergic polymorphic ventricular tachycardia from engineered human heart tissue

BACKGROUND: Modeling of human arrhythmias using induced pluripotent stem cell-derived cardiomyocytes has focused on single cell phenotypes. However, arrhythmias are the emergent properties of cells assembled into tissues, and the impact of inherited arrhythmia mutations on tissue-level properties of...

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Pubblicato in:Circulation
Autori principali: Park, Sung-Jin, Zhang, Donghui, Qi, Yan, Li, Yifei, Lee, Keel Yong, Bezzerides, Vassilios J., Yang, Pengcheng, Xia, Shutao, Kim, Sean L., Liu, Xujie, Lu, Fujian, Pasqualini, Francesco S., Campbell, Patrick H., Geva, Judith, Roberts, Amy E., Kleber, Andre G., Abrams, Dominic J., Pu, William T., Parker, Kevin Kit
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750809/
https://ncbi.nlm.nih.gov/pubmed/31311300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.119.039711
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