Gene therapy for catecholaminergic polymorphic ventricular tachycardia by inhibition of Ca(2+)/calmodulin-dependent kinase II

BACKGROUND: Catecholaminergic polymorphic ventricular tachycardia (CPVT), an inherited cardiac arrhythmia characterized by adrenergically triggered arrhythmias, is inadequately treated by current standard of care. Ca(2+)/calmodulin-dependent protein kinase II (CaMKII), an adrenergically activated ki...

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Veröffentlicht in:Circulation
Hauptverfasser: Bezzerides, Vassilios J., Caballero, Ana, Wang, Suya, Ai, Yulan, Hylind, Robyn J., Lu, Fujian, Heims-Waldron, Danielle A., Chambers, Kristina D., Zhang, Donghui, Abrams, Dominic J., Pu, William T.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7274838/
https://ncbi.nlm.nih.gov/pubmed/31155924
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.118.038514
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