Insights into the pathogenesis of catecholaminergic polymorphic ventricular tachycardia from engineered human heart tissue

BACKGROUND: Modeling of human arrhythmias using induced pluripotent stem cell-derived cardiomyocytes has focused on single cell phenotypes. However, arrhythmias are the emergent properties of cells assembled into tissues, and the impact of inherited arrhythmia mutations on tissue-level properties of...

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Foilsithe in:Circulation
Main Authors: Park, Sung-Jin, Zhang, Donghui, Qi, Yan, Li, Yifei, Lee, Keel Yong, Bezzerides, Vassilios J., Yang, Pengcheng, Xia, Shutao, Kim, Sean L., Liu, Xujie, Lu, Fujian, Pasqualini, Francesco S., Campbell, Patrick H., Geva, Judith, Roberts, Amy E., Kleber, Andre G., Abrams, Dominic J., Pu, William T., Parker, Kevin Kit
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2019
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Article
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750809/
https://ncbi.nlm.nih.gov/pubmed/31311300
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/CIRCULATIONAHA.119.039711
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