Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis

Cellular heterogeneity is frequently observed in cancer, but the biological significance of heterogeneous tumor clones is not well defined. Using multicolor reporters and CRISPR-Cas9 barcoding, we trace clonal dynamics in a mouse model of sarcoma. We show that primary tumor growth is associated with...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Cell Rep
Egile Nagusiak: Tang, Yuning J., Huang, Jianguo, Tsushima, Hidetoshi, Ban, Ga I., Zhang, Hongyuan, Oristian, Kristianne M., Puviindran, Vijitha, Williams, Nerissa, Ding, Xiruo, Ou, Jianhong, Jung, Sin-Ho, Lee, Chang-Lung, Jiao, Yiqun, Chen, Benny J., Kirsch, David G., Alman, Benjamin A.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750751/
https://ncbi.nlm.nih.gov/pubmed/31509746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.029
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