Tracing Tumor Evolution in Sarcoma Reveals Clonal Origin of Advanced Metastasis

Cellular heterogeneity is frequently observed in cancer, but the biological significance of heterogeneous tumor clones is not well defined. Using multicolor reporters and CRISPR-Cas9 barcoding, we trace clonal dynamics in a mouse model of sarcoma. We show that primary tumor growth is associated with...

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Detaylı Bibliyografya
Yayımlandı:Cell Rep
Asıl Yazarlar: Tang, Yuning J., Huang, Jianguo, Tsushima, Hidetoshi, Ban, Ga I., Zhang, Hongyuan, Oristian, Kristianne M., Puviindran, Vijitha, Williams, Nerissa, Ding, Xiruo, Ou, Jianhong, Jung, Sin-Ho, Lee, Chang-Lung, Jiao, Yiqun, Chen, Benny J., Kirsch, David G., Alman, Benjamin A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2019
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750751/
https://ncbi.nlm.nih.gov/pubmed/31509746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.029
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