Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis

During enchondral ossification, mesenchymal cells express genes regulating the intracellular biosynthesis of cholesterol and lipids. Here, we have investigated conditional deletion of Scap or of Insig1 and Insig2 (Scap inhibits intracellular biosynthesis and Insig proteins activate intracellular bio...

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Enregistré dans:
Détails bibliographiques
Publié dans:Development
Auteurs principaux: Tsushima, Hidetoshi, Tang, Yuning J., Puviindran, Vijitha, Hsu, Shu-Hsuan Claire, Nadesan, Puviindran, Yu, Chunying, Zhang, Hongyuan, Mirando, Anthony J., Hilton, Matthew J., Alman, Benjamin A.
Format: Artigo
Langue:Inglês
Publié: The Company of Biologists Ltd 2018
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053657/
https://ncbi.nlm.nih.gov/pubmed/29899135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.162396
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