Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis

During enchondral ossification, mesenchymal cells express genes regulating the intracellular biosynthesis of cholesterol and lipids. Here, we have investigated conditional deletion of Scap or of Insig1 and Insig2 (Scap inhibits intracellular biosynthesis and Insig proteins activate intracellular bio...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Development
Prif Awduron: Tsushima, Hidetoshi, Tang, Yuning J., Puviindran, Vijitha, Hsu, Shu-Hsuan Claire, Nadesan, Puviindran, Yu, Chunying, Zhang, Hongyuan, Mirando, Anthony J., Hilton, Matthew J., Alman, Benjamin A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Company of Biologists Ltd 2018
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053657/
https://ncbi.nlm.nih.gov/pubmed/29899135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.162396
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