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Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis

During enchondral ossification, mesenchymal cells express genes regulating the intracellular biosynthesis of cholesterol and lipids. Here, we have investigated conditional deletion of Scap or of Insig1 and Insig2 (Scap inhibits intracellular biosynthesis and Insig proteins activate intracellular bio...

Πλήρης περιγραφή

Αποθηκεύτηκε σε:
Λεπτομέρειες βιβλιογραφικής εγγραφής
Τόπος έκδοσης:Development
Κύριοι συγγραφείς: Tsushima, Hidetoshi, Tang, Yuning J., Puviindran, Vijitha, Hsu, Shu-Hsuan Claire, Nadesan, Puviindran, Yu, Chunying, Zhang, Hongyuan, Mirando, Anthony J., Hilton, Matthew J., Alman, Benjamin A.
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: The Company of Biologists Ltd 2018
Θέματα:
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053657/
https://ncbi.nlm.nih.gov/pubmed/29899135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.162396
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