Intracellular biosynthesis of lipids and cholesterol by Scap and Insig in mesenchymal cells regulates long bone growth and chondrocyte homeostasis

During enchondral ossification, mesenchymal cells express genes regulating the intracellular biosynthesis of cholesterol and lipids. Here, we have investigated conditional deletion of Scap or of Insig1 and Insig2 (Scap inhibits intracellular biosynthesis and Insig proteins activate intracellular bio...

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Detaylı Bibliyografya
Yayımlandı:Development
Asıl Yazarlar: Tsushima, Hidetoshi, Tang, Yuning J., Puviindran, Vijitha, Hsu, Shu-Hsuan Claire, Nadesan, Puviindran, Yu, Chunying, Zhang, Hongyuan, Mirando, Anthony J., Hilton, Matthew J., Alman, Benjamin A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Company of Biologists Ltd 2018
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6053657/
https://ncbi.nlm.nih.gov/pubmed/29899135
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dev.162396
Etiketler: Etiketle
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