miR-147b-mediated TCA cycle dysfunction and pseudohypoxia initiate drug tolerance to EGFR inhibitors in lung adenocarcinoma

Drug-tolerance is an acute defense response prior to a fully drug-resistant state and tumor relapse, however there are few therapeutic agents targeting drug-tolerance in the clinic. Here we show that miR-147b initiates a reversible tolerant-state to the EGFR inhibitor osimertinib in non-small cell l...

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Detalhes bibliográficos
Publicado no:Nat Metab
Main Authors: Zhang, Wen Cai, Wells, Julie M., Chow, Kin-Hoe, Huang, He, Yuan, Min, Saxena, Tanvi, Melnick, Mary Ann, Politi, Katerina, Asara, John M., Costa, Daniel B., Bult, Carol J., Slack, Frank J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6750230/
https://ncbi.nlm.nih.gov/pubmed/31535082
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s42255-019-0052-9
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