Replication stress induces mitotic death through parallel pathways regulated by WAPL and telomere deprotection

Mitotic catastrophe is a broad descriptor encompassing unclear mechanisms of cell death. Here we investigate replication stress-driven mitotic catastrophe in human cells and identify that replication stress principally induces mitotic death signalled through two independent pathways. In p53-compromi...

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Udgivet i:Nat Commun
Main Authors: Masamsetti, V. Pragathi, Low, Ronnie Ren Jie, Mak, Ka Sin, O’Connor, Aisling, Riffkin, Chris D., Lamm, Noa, Crabbe, Laure, Karlseder, Jan, Huang, David C. S., Hayashi, Makoto T., Cesare, Anthony J.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748914/
https://ncbi.nlm.nih.gov/pubmed/31530811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12255-w
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