ABIN-1 heterozygosity sensitizes to innate immune response in both RIPK1-dependent and RIPK1-independent manner

ABIN-1 (encoded by the gene Tnip1) is a ubiquitin-binding protein that can interact with ubiquitin-editing enzyme A20 (encoded by the gene TNFAIP3) to restrain the activation of necroptosis and NF-κB activation. Genetic variants in the genes Tnip1 and TNFAIP3 are both strongly associated with suscep...

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Udgivet i:Cell Death Differ
Main Authors: Su, Zhenyi, Dziedzic, Slawomir A., Hu, Die, Barrett, Vica Jean, Broekema, Nicole, Li, Wanjin, Qian, Lihui, Jia, Na, Ofengeim, Dimitry, Najafov, Ayaz, Zhu, Hong, Knipe, David M., Yuan, Junying
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748150/
https://ncbi.nlm.nih.gov/pubmed/30341420
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0215-3
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