mTOR-dependent upregulation of xCT blocks melanin synthesis and promotes tumorigenesis

Loss of either TSC1 or TSC2 causes tuberous sclerosis complex (TSC) via activation of mTOR signaling pathway. The two prominent features of TSC are skin lesions including hypomelanic macules and benign tumors in multiple organs, whose molecular alterations are largely unknown. We report here that X(...

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Pubblicato in:Cell Death Differ
Autori principali: Li, Chunjia, Chen, Hongyu, Lan, Zhou, He, Shaozong, Chen, Rongrong, Wang, Fang, Liu, Zhibo, Li, Kai, Cheng, Lili, Liu, Ye, Sun, Kun, Wan, Xiaofeng, Chen, Xinxin, Peng, Haiyong, Li, Li, Zhang, Yanjun, Jing, Yanling, Huang, Min, Wang, Yanan, Wang, Yan, Jiang, Jiandong, Zha, Xiaojun, Chen, Ligong, Zhang, Hongbing
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748149/
https://ncbi.nlm.nih.gov/pubmed/30760873
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-019-0274-0
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