PDK4 Protein Promotes Tumorigenesis through Activation of cAMP-response Element-binding Protein (CREB)-Ras Homolog Enriched in Brain (RHEB)-mTORC1 Signaling Cascade

Mechanistic target of rapamycin (mTOR) integrates multiple extracellular and intracellular signals to regulate cell growth and survival. Hyperactivation of mTOR has been observed in various cancers. Regulation of mTOR activity is thus of importance in physiological processes and tumor development. H...

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Bibliografiska uppgifter
Huvudupphovsmän: Liu, Zhibo, Chen, Xinxin, Wang, Ying, Peng, Haiyong, Wang, Yanan, Jing, Yanling, Zhang, Hongbing
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Biochemistry and Molecular Biology 2014
Ämnen:
Cell Biology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4207987/
https://ncbi.nlm.nih.gov/pubmed/25164809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.584821
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