Mammalian target of rapamycin up-regulation of pyruvate kinase isoenzyme type M2 is critical for aerobic glycolysis and tumor growth

Although aerobic glycolysis (the Warburg effect) is a hallmark of cancer, key questions, including when, how, and why cancer cells become highly glycolytic, remain less clear. For a largely unknown regulatory mechanism, a rate-limiting glycolytic enzyme pyruvate kinase M2 (PKM2) isoform is exclusive...

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Главные авторы: Sun, Qian, Chen, Xinxin, Ma, Jianhui, Peng, Haiyong, Wang, Fang, Zha, Xiaojun, Wang, Yanan, Jing, Yanling, Yang, Hongwang, Chen, Rongrong, Chang, Long, Zhang, Yu, Goto, June, Onda, Hiroaki, Chen, Tong, Wang, Ming-Rong, Lu, Youyong, You, Han, Kwiatkowski, David, Zhang, Hongbing
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2011
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3054028/
https://ncbi.nlm.nih.gov/pubmed/21325052
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1014769108
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