Mammalian target of rapamycin regulates murine and human cell differentiation through STAT3/p63/Jagged/Notch cascade

The receptor tyrosine kinase/PI3K/AKT/mammalian target of rapamycin (RTK/PI3K/AKT/mTOR) pathway is frequently altered in cancer, but the underlying mechanism leading to tumorigenesis by activated mTOR remains less clear. Here we show that mTOR is a positive regulator of Notch signaling in mouse and...

Full description

Saved in:
Bibliographic Details
Main Authors: Ma, Jianhui, Meng, Yan, Kwiatkowski, David J., Chen, Xinxin, Peng, Haiyong, Sun, Qian, Zha, Xiaojun, Wang, Fang, Wang, Ying, Jing, Yanling, Zhang, Shu, Chen, Rongrong, Wang, Lianmei, Wu, Erxi, Cai, Guifang, Malinowska-Kolodziej, Izabela, Liao, Qi, Liu, Yuqin, Zhao, Yi, Sun, Qiang, Xu, Kaifeng, Dai, Jianwu, Han, Jiahuai, Wu, Lizi, Zhao, Robert Chunhua, Shen, Huangxuan, Zhang, Hongbing
Format: Artigo
Language:Inglês
Published: American Society for Clinical Investigation 2009
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2798675/
https://ncbi.nlm.nih.gov/pubmed/20038814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI37964
Tags: Add Tag
No Tags, Be the first to tag this record!

Similar Items