Calcium dysregulation mediates mitochondrial and neurite outgrowth abnormalities in SOD2 deficient embryonic cerebral cortical neurons

Mitochondrial superoxide dismutase 2 (SOD2) is a major antioxidant defense enzyme. Here we provide evidence that SOD2 plays critical roles in maintaining calcium homeostasis in newly generated embryonic cerebral cortical neurons, which is essential for normal mitochondrial function and subcellular d...

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Vydáno v:Cell Death Differ
Hlavní autoři: Zhao, Qijin, Lu, Daoyuan, Wang, Jing, Liu, Beibei, Cheng, Heping, Mattson, Mark P., Cheng, Aiwu
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2018
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748124/
https://ncbi.nlm.nih.gov/pubmed/30390091
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0230-4
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