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Numb-Mediated Neurite Outgrowth is Isoform-Dependent, and Requires Activation of Voltage-Dependent Calcium Channels

Numb is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells by unknown mechanisms. Here we report that the neural cells expressing Numb isoforms with short phosphotyrosine-binding domain (SPTB) undergo extensive neurite outgrowth, an effect that can be...

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Detalhes bibliográficos
Main Authors: Lu, Cheng B., Fu, Weiming, Xu, Xiangru, Mattson, Mark P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692829/
https://ncbi.nlm.nih.gov/pubmed/19344753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2009.03.063
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