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Numb-Mediated Neurite Outgrowth is Isoform-Dependent, and Requires Activation of Voltage-Dependent Calcium Channels

Numb is an evolutionarily conserved protein that controls the differentiation of neuronal progenitor cells by unknown mechanisms. Here we report that the neural cells expressing Numb isoforms with short phosphotyrosine-binding domain (SPTB) undergo extensive neurite outgrowth, an effect that can be...

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Autors principals: Lu, Cheng B., Fu, Weiming, Xu, Xiangru, Mattson, Mark P.
Format: Artigo
Idioma:Inglês
Publicat: 2009
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2692829/
https://ncbi.nlm.nih.gov/pubmed/19344753
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2009.03.063
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