MicroRNA-197 controls ADAM10 expression to mediate MeCP2’s role in the differentiation of neuronal progenitors

Duplication of MECP2 (Methyl-CpG-binding protein 2) causes severe mental illness called MECP2 duplication syndrome (MDS), yet the underlying mechanism remains elusive. Here we show, in Tg(MECP2) transgenic mouse brain or cultured neural progenitor cells (NPCs), that elevated MeCP2 expression promote...

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Udgivet i:Cell Death Differ
Main Authors: Wang, Yu-Meng, Zheng, Yu-Fang, Yang, Si-Yu, Yang, Zhang-Min, Zhang, Lin-Na, He, Yan-Qin, Gong, Xiao-Hong, Liu, Dong, Finnell, Richard H., Qiu, Zi-Long, Du, Ya-Song, Wang, Hong-Yan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2018
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6748079/
https://ncbi.nlm.nih.gov/pubmed/30560934
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41418-018-0257-6
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