Integrated Metabolomics-DNA Methylation Analysis Reveals Significant Long-Term Tissue-Dependent Directional Alterations in Aminoacyl-tRNA Biosynthesis in the Left Ventricle of the Heart and Hippocampus Following Proton Irradiation

In this study, an untargeted metabolomics approach was used to assess the effects of proton irradiation (1 Gy of 150 MeV) on the metabolome and DNA methylation pattern in the murine hippocampus and left ventricle of the heart 22 weeks following exposure using an integrated metabolomics-DNA methylati...

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Vydáno v:Front Mol Biosci
Hlavní autoři: Torres, Eileen Ruth S., Hall, Reed, Bobe, Gerd, Choi, Jaewoo, Impey, Soren, Pelz, Carl, Lindner, Jonathan R., Stevens, Jan F., Raber, Jacob
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Molecular Biosciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746933/
https://ncbi.nlm.nih.gov/pubmed/31552266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2019.00077
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