Integrated Metabolomics-DNA Methylation Analysis Reveals Significant Long-Term Tissue-Dependent Directional Alterations in Aminoacyl-tRNA Biosynthesis in the Left Ventricle of the Heart and Hippocampus Following Proton Irradiation

In this study, an untargeted metabolomics approach was used to assess the effects of proton irradiation (1 Gy of 150 MeV) on the metabolome and DNA methylation pattern in the murine hippocampus and left ventricle of the heart 22 weeks following exposure using an integrated metabolomics-DNA methylati...

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Detalhes bibliográficos
Publicado no:Front Mol Biosci
Main Authors: Torres, Eileen Ruth S., Hall, Reed, Bobe, Gerd, Choi, Jaewoo, Impey, Soren, Pelz, Carl, Lindner, Jonathan R., Stevens, Jan F., Raber, Jacob
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Molecular Biosciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746933/
https://ncbi.nlm.nih.gov/pubmed/31552266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2019.00077
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