Integrated Metabolomics-DNA Methylation Analysis Reveals Significant Long-Term Tissue-Dependent Directional Alterations in Aminoacyl-tRNA Biosynthesis in the Left Ventricle of the Heart and Hippocampus Following Proton Irradiation

In this study, an untargeted metabolomics approach was used to assess the effects of proton irradiation (1 Gy of 150 MeV) on the metabolome and DNA methylation pattern in the murine hippocampus and left ventricle of the heart 22 weeks following exposure using an integrated metabolomics-DNA methylati...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Front Mol Biosci
Prif Awduron: Torres, Eileen Ruth S., Hall, Reed, Bobe, Gerd, Choi, Jaewoo, Impey, Soren, Pelz, Carl, Lindner, Jonathan R., Stevens, Jan F., Raber, Jacob
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Frontiers Media S.A. 2019
Pynciau:
Molecular Biosciences
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746933/
https://ncbi.nlm.nih.gov/pubmed/31552266
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmolb.2019.00077
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