Apolipoprotein E4 and Insulin Resistance Interact to Impair Cognition and Alter the Epigenome and Metabolome

Apolipoprotein E4 (E4) and type 2 diabetes are major risk factors for cognitive decline and late onset Alzheimer’s disease (AD). E4-associated phenotypes and insulin resistance (IR) share several features and appear to interact in driving cognitive dysfunction. However, shared mechanisms that could...

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Vydáno v:Sci Rep
Hlavní autoři: Johnson, Lance A., Torres, Eileen Ruth S., Impey, Soren, Stevens, Jan F., Raber, Jacob
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2017
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5341123/
https://ncbi.nlm.nih.gov/pubmed/28272510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep43701
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