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Mapping the protein–protein and genetic interactions of cancer to guide precision medicine

Massive efforts to sequence cancer genomes have compiled an impressive catalogue of cancer mutations, revealing the recurrent exploitation of a handful of ‘hallmark cancer pathways’. However, unraveling how sets of mutated proteins in these and other pathways hijack pro-proliferative signaling netwo...

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Bibliographic Details
Published in:Curr Opin Genet Dev
Main Authors: Bouhaddou, Mehdi, Eckhardt, Manon, Naing, Zun Zar Chi, Kim, Minkyu, Ideker, Trey, Krogan, Nevan J
Format: Artigo
Language:Inglês
Published: 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746583/
https://ncbi.nlm.nih.gov/pubmed/31288129
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.gde.2019.04.005
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