A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences

[Image: see text] The nuclear retinoid X receptors (RXRs) are key ligand sensing transcription factors that serve as universal nuclear receptor heterodimer partners and are thus involved in numerous physiological processes. Therapeutic targeting of RXRs holds high potential but available RXR activat...

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Bibliografiska uppgifter
I publikationen:ACS Med Chem Lett
Huvudupphovsmän: Pollinger, Julius, Schierle, Simone, Gellrich, Leonie, Ohrndorf, Julia, Kaiser, Astrid, Heitel, Pascal, Chaikuad, Apirat, Knapp, Stefan, Merk, Daniel
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Chemical Society 2019
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746191/
https://ncbi.nlm.nih.gov/pubmed/31531208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00306
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