A Novel Biphenyl-based Chemotype of Retinoid X Receptor Ligands Enables Subtype and Heterodimer Preferences

[Image: see text] The nuclear retinoid X receptors (RXRs) are key ligand sensing transcription factors that serve as universal nuclear receptor heterodimer partners and are thus involved in numerous physiological processes. Therapeutic targeting of RXRs holds high potential but available RXR activat...

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Bibliografiske detaljer
Udgivet i:ACS Med Chem Lett
Main Authors: Pollinger, Julius, Schierle, Simone, Gellrich, Leonie, Ohrndorf, Julia, Kaiser, Astrid, Heitel, Pascal, Chaikuad, Apirat, Knapp, Stefan, Merk, Daniel
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2019
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6746191/
https://ncbi.nlm.nih.gov/pubmed/31531208
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acsmedchemlett.9b00306
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