Transcriptomic and Epigenomic Profiling of Histone Deacetylase Inhibitor Treatment Reveals Distinct Gene Regulation Profiles Leading to Impaired Neutrophil Development

The clinical use of histone deacetylase inhibitors (HDACi) for the treatment of bone marrow failure and hematopoietic malignancies has increased dramatically over the last decades. Nonetheless, their effects on normal myelopoiesis remain poorly evaluated. Here, we treated cord blood derived CD34+ pr...

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發表在:Hemasphere
Main Authors: Govers, Anita M.A.P., Wiggers, Caroline R.M., van Boxtel, Ruben, Mokry, Michal, Nieuwenhuis, Edward E.S., Creyghton, Menno P., Bartels, Marije, Coffer, Paul J.
格式: Artigo
語言:Inglês
出版: Wolters Kluwer Health 2019
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6745919/
https://ncbi.nlm.nih.gov/pubmed/31723844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/HS9.0000000000000270
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