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Computational Redesign of PD-1 Interface for PD-L1 Ligand Selectivity
Chronic or persistent stimulation of the programmed cell death-1 (PD-1) pathway prevents T cells from mounting anti-tumor and anti-viral immune responses. Blockade of this inhibitory checkpoint pathway has shown therapeutic importance by rescuing T cells from their exhausted state. Cognate ligands o...
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| Publié dans: | Structure |
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| Auteurs principaux: | , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2019
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6745709/ https://ncbi.nlm.nih.gov/pubmed/30930066 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2019.03.006 |
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