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Redesigning HVEM interface for selective binding to LIGHT, BTLA, and CD160

Herpes virus entry mediator (HVEM) regulates positive and negative signals for T-cell activation through co-signaling pathways. Dysfunction of the HVEM co-signaling network is associated with multiple pathologies related to autoimmunity, infectious disease and cancer, making the associated molecules...

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Publicat a:Structure
Autors principals: Shrestha, Rojan, Garrett-Thomson, Sarah, Liu, Weifeng, Almo, Steven C., Fiser, Andras
Format: Artigo
Idioma:Inglês
Publicat: 2020
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7642093/
https://ncbi.nlm.nih.gov/pubmed/32795404
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2020.07.013
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