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Computational Redesign of PD-1 Interface for PD-L1 Ligand Selectivity

Chronic or persistent stimulation of the programmed cell death-1 (PD-1) pathway prevents T cells from mounting anti-tumor and anti-viral immune responses. Blockade of this inhibitory checkpoint pathway has shown therapeutic importance by rescuing T cells from their exhausted state. Cognate ligands o...

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Publicat a:Structure
Autors principals: Shrestha, Rojan, Garrett, Sarah C., Almo, Steven C., Fiser, Andras
Format: Artigo
Idioma:Inglês
Publicat: 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6745709/
https://ncbi.nlm.nih.gov/pubmed/30930066
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.str.2019.03.006
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