FTY720-Mitoxy Reduces Toxicity Associated with α-Synuclein and Oxidative Stress by Increasing Trophic Factor Expression and Myelin Protein in OLN-93 Oligodendroglia Cell Cultures

Multiple system atrophy (MSA) is a fatal demyelinating disorder lacking any disease-modifying therapies. MSA pathology stems from aggregated α-synuclein (aSyn) accumulation in glial cytosolic inclusions of oligodendroglial cell (OLGs), the myelinating cells of brain. In MSA brains and in MSA animal...

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Опубликовано в: :Neuropharmacology
Главные авторы: Vargas-Medrano, Javier, Segura-Ulate, Ismael, Yang, Barbara, Chinnasamy, Ramesh, Arterburn, Jeffrey B., Perez, Ruth G.
Формат: Artigo
Язык:Inglês
Опубликовано: 2019
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6745250/
https://ncbi.nlm.nih.gov/pubmed/31291595
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2019.107701
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