Inventories of naive and tolerant mouse CD4 T cell repertoires reveal a hierarchy of deleted and diverted T cell receptors

Deletion or T(reg) cell differentiation are alternative fates of autoreactive MHCII-restricted thymocytes. How these different modes of tolerance determine the size and composition of polyclonal cohorts of autoreactive T cells with shared specificity is poorly understood. We addressed how tolerance...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Hassler, Tobias, Urmann, Emanuel, Teschner, Sebastian, Federle, Christine, Dileepan, Thamotharampillai, Schober, Kilian, Jenkins, Marc K., Busch, Dirk H., Hinterberger, Maria, Klein, Ludger
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744931/
https://ncbi.nlm.nih.gov/pubmed/31451631
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1907615116
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