B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma

Tumor associated inflammation predicts response to immune checkpoint blockade in human melanoma. Current theories on regulation of inflammation center on anti-tumor T cell responses. Here we show that tumor associated B cells are vital to melanoma associated inflammation. Human B cells express pro-...

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Publicat a:Nat Commun
Autors principals: Griss, Johannes, Bauer, Wolfgang, Wagner, Christine, Simon, Martin, Chen, Minyi, Grabmeier-Pfistershammer, Katharina, Maurer-Granofszky, Margarita, Roka, Florian, Penz, Thomas, Bock, Christoph, Zhang, Gao, Herlyn, Meenhard, Glatz, Katharina, Läubli, Heinz, Mertz, Kirsten D., Petzelbauer, Peter, Wiesner, Thomas, Hartl, Markus, Pickl, Winfried F., Somasundaram, Rajasekharan, Steinberger, Peter, Wagner, Stephan N.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744450/
https://ncbi.nlm.nih.gov/pubmed/31519915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12160-2
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