B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma

Tumor associated inflammation predicts response to immune checkpoint blockade in human melanoma. Current theories on regulation of inflammation center on anti-tumor T cell responses. Here we show that tumor associated B cells are vital to melanoma associated inflammation. Human B cells express pro-...

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Publicado no:Nat Commun
Main Authors: Griss, Johannes, Bauer, Wolfgang, Wagner, Christine, Simon, Martin, Chen, Minyi, Grabmeier-Pfistershammer, Katharina, Maurer-Granofszky, Margarita, Roka, Florian, Penz, Thomas, Bock, Christoph, Zhang, Gao, Herlyn, Meenhard, Glatz, Katharina, Läubli, Heinz, Mertz, Kirsten D., Petzelbauer, Peter, Wiesner, Thomas, Hartl, Markus, Pickl, Winfried F., Somasundaram, Rajasekharan, Steinberger, Peter, Wagner, Stephan N.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744450/
https://ncbi.nlm.nih.gov/pubmed/31519915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12160-2
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