B cells sustain inflammation and predict response to immune checkpoint blockade in human melanoma

Tumor associated inflammation predicts response to immune checkpoint blockade in human melanoma. Current theories on regulation of inflammation center on anti-tumor T cell responses. Here we show that tumor associated B cells are vital to melanoma associated inflammation. Human B cells express pro-...

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Pubblicato in:Nat Commun
Autori principali: Griss, Johannes, Bauer, Wolfgang, Wagner, Christine, Simon, Martin, Chen, Minyi, Grabmeier-Pfistershammer, Katharina, Maurer-Granofszky, Margarita, Roka, Florian, Penz, Thomas, Bock, Christoph, Zhang, Gao, Herlyn, Meenhard, Glatz, Katharina, Läubli, Heinz, Mertz, Kirsten D., Petzelbauer, Peter, Wiesner, Thomas, Hartl, Markus, Pickl, Winfried F., Somasundaram, Rajasekharan, Steinberger, Peter, Wagner, Stephan N.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744450/
https://ncbi.nlm.nih.gov/pubmed/31519915
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-12160-2
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