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Intercalating TOP2 Poisons Attenuate Topoisomerase Action at Higher Concentrations
Topoisomerase II (TOP2) poisons are effective cytotoxic anticancer agents that stabilize the normally transient TOP2-DNA covalent complexes formed during the enzyme reaction cycle. These drugs include etoposide, mitoxantrone, and the anthracyclines doxorubicin and epirubicin. Anthracyclines also exe...
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| Publicado no: | Mol Pharmacol |
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| Main Authors: | , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Pharmacology and Experimental Therapeutics
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6744389/ https://ncbi.nlm.nih.gov/pubmed/31399497 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.119.117259 |
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