AKR1D1 is a novel regulator of metabolic phenotype in human hepatocytes and is dysregulated in non-alcoholic fatty liver disease

OBJECTIVE: Non-alcoholic fatty liver disease (NAFLD) is the hepatic manifestation of metabolic syndrome. Steroid hormones and bile acids are potent regulators of hepatic carbohydrate and lipid metabolism. Steroid 5β-reductase (AKR1D1) is highly expressed in human liver where it inactivates steroid h...

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Pubblicato in:Metabolism
Autori principali: Nikolaou, Nikolaos, Gathercole, Laura L., Marchand, Lea, Althari, Sara, Dempster, Niall J., Green, Charlotte J., van de Bunt, Martijn, McNeil, Catriona, Arvaniti, Anastasia, Hughes, Beverly A., Sgromo, Bruno, Gillies, Richard S., Marschall, Hanns-Ulrich, Penning, Trevor M., Ryan, John, Arlt, Wiebke, Hodson, Leanne, Tomlinson, Jeremy W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: W.B. Saunders 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744372/
https://ncbi.nlm.nih.gov/pubmed/31330134
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.metabol.2019.153947
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