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Impact of mTOR hyperactive neurons on the morphology and physiology of adjacent neurons: Do PTEN KO cells make bad neighbors?

Hyperactivation of the mechanistic target of rapamycin (mTOR) pathway is associated with epilepsy, autism and brain growth abnormalities in humans. mTOR hyperactivation often results from developmental somatic mutations, producing genetic lesions and associated dysfunction in relatively restricted p...

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Detalhes bibliográficos
Publicado no:Exp Neurol
Main Authors: LaSarge, Candi L., Pun, Raymund Y.K., Gu, Zhiqing, Santos, Victor R., Danzer, Steve C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6744293/
https://ncbi.nlm.nih.gov/pubmed/31377403
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2019.113029
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