PTEN deletion increases hippocampal granule cell excitability in male and female mice

Deletion of the mTOR pathway inhibitor PTEN from postnatally-generated hippocampal dentate granule cells causes epilepsy. Here, we conducted field potential, whole cell recording and single cell morphology studies to begin to elucidate the mechanisms by which granule cell-specific PTEN-loss produces...

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Bibliografiske detaljer
Udgivet i:Neurobiol Dis
Main Authors: Santos, Victor R., Pun, Raymund Y.K., Arafa, Salwa R., LaSarge, Candi L., Rowley, Shane, Khademi, Shadi, Bouley, Tom, Holland, Katherine D., Garcia-Cairasco, Norberto, Danzer, Steve C.
Format: Artigo
Sprog:Inglês
Udgivet: 2017
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5675774/
https://ncbi.nlm.nih.gov/pubmed/28855130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.nbd.2017.08.014
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