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Self-reinforcing effects of mTOR hyperactive neurons on dendritic growth

Loss of the mTOR pathway negative regulator PTEN from hippocampal dentate granule cells leads to neuronal hypertrophy, increased dendritic branching and aberrant basal dendrite formation in animal models. Similar changes are evident in humans with mTOR pathway mutations. These genetic conditions are...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Exp Neurol
Egile Nagusiak: Arafa, Salwa R., LaSarge, Candi L., Pun, Raymund Y.K., Khademi, Shadi, Danzer, Steve C.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2018
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6263818/
https://ncbi.nlm.nih.gov/pubmed/30268766
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2018.09.019
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