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Self-reinforcing effects of mTOR hyperactive neurons on dendritic growth
Loss of the mTOR pathway negative regulator PTEN from hippocampal dentate granule cells leads to neuronal hypertrophy, increased dendritic branching and aberrant basal dendrite formation in animal models. Similar changes are evident in humans with mTOR pathway mutations. These genetic conditions are...
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| Pubblicato in: | Exp Neurol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2018
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6263818/ https://ncbi.nlm.nih.gov/pubmed/30268766 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.expneurol.2018.09.019 |
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