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Combinatorial diversity of Syk recruitment driven by its multivalent engagement with FcεRIγ
Syk/Zap70 family kinases are essential for signaling via multichain immune-recognition receptors such as tetrameric (αβγ2) FcεRI. Syk activation is generally attributed to cis binding of its tandem SH2 domains to dual phosphotyrosines within FcεRIγ-ITAMs (immunoreceptor tyrosine-based activation mot...
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| Publicado no: | Mol Biol Cell |
|---|---|
| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Cell Biology
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6743456/ https://ncbi.nlm.nih.gov/pubmed/31216232 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E18-11-0722 |
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