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Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics
Cross-linking of immunoglobulin E–bound FcεRI triggers multiple cellular responses, including degranulation and cytokine production. Signaling is dependent on recruitment of Syk via docking of its dual SH2 domains to phosphorylated tyrosines within the FcεRI immunoreceptor tyrosine-based activation...
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| Опубликовано в: : | Mol Biol Cell |
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| Главные авторы: | , , , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
The American Society for Cell Biology
2017
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5687039/ https://ncbi.nlm.nih.gov/pubmed/28855374 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-06-0350 |
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