Differential mast cell outcomes are sensitive to FcεRI-Syk binding kinetics

Cross-linking of immunoglobulin E–bound FcεRI triggers multiple cellular responses, including degranulation and cytokine production. Signaling is dependent on recruitment of Syk via docking of its dual SH2 domains to phosphorylated tyrosines within the FcεRI immunoreceptor tyrosine-based activation...

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Détails bibliographiques
Publié dans:Mol Biol Cell
Auteurs principaux: Schwartz, Samantha L., Cleyrat, Cédric, Olah, Mark J., Relich, Peter K., Phillips, Genevieve K., Hlavacek, William S., Lidke, Keith A., Wilson, Bridget S., Lidke, Diane S.
Format: Artigo
Langue:Inglês
Publié: The American Society for Cell Biology 2017
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5687039/
https://ncbi.nlm.nih.gov/pubmed/28855374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E17-06-0350
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